Investigating the Role of MicroRNAs in The Pathogenesis and Progression of Hepatocellular Carcinoma

Abstract

The primary regulators of the cellular pathways implicated in virus-induced pathogenesis include a variety of host factors, including proteins and microRNAs (miRNAs). Numerous secretory chemicals that are secreted from virus-infected cells aid in cell-to-cell communication and foster a microenvironment that promotes cellular pathogenesis, both of which advance the course of the disease. One of the main parts of secretive substances is exosomes. They are the small extracellular vesicles, secreted out by the cells and have a significant role in cell-to-cell signaling. They typically represent the state of the cell and are made up of several host components such as cellular proteins, lncRNAs, mRNAs, and miRNA. Exosomes, which are vesicles that originate inside cells as multivesicular bodies and are ejected from the cell upon fusion with the cell membrane, will exhibit any changes in the composition of the cell. All things considered, the work shows that exosome proteins and miRNA may play a part in host response and viral tactics, which may together accelerate the course of the disease and provide new targets for potential treatment.